Unions against governments: explaining general strikes in Western Europe, 1980-2006

Across Western Europe, unions have increasingly engaged in staging general strikes against governments since 1980. This increase in general strikes is puzzling as it has occurred at the same time as economic strikes have been on the decline. We posit that theories developed to explain economic strikes hold little explanatory power in accounting for variation in general strikes across countries and over time. Instead, we develop a framework based on political variables; in particular, whether governments have included or excluded unions in framing policy reforms; the party position of the government; and the type of government. Our empirical analysis, based on a conditional fixed-effects logit estimation of 84 general strikes between 1980 and 2006, shows that union exclusion from the process of reforming policies, government strength, and the party position of the government can provide an initial explanation for the occurrence of general strikes

Axions and saxions from the primordial supersymmetric plasma and extra radiation signatures

We calculate the rate for thermal production of axions and saxions via scattering of quarks, gluons, squarks, and gluinos in the primordial supersymmetric plasma. Systematic field theoretical methods such as hard thermal loop resummation are applied to obtain a finite result in a gauge-invariant way that is consistent to leading order in the strong gauge coupling. We calculate the thermally produced yield and the decoupling temperature for both axions and saxions. For the generic case in which saxion decays into axions are possible, the emitted axions can constitute extra radiation already prior to big bang nucleosynthesis and well thereafter. We update associated limits imposed by recent studies of the primordial helium-4 abundance and by precision cosmology of the cosmic microwave background and large scale structure. We show that the trend towards extra radiation seen in those studies can be explained by late decays of thermal saxions into axions and that upcoming Planck results will probe supersymmetric axion models with unprecedented sensitivity.Comment: 16 pages, 7 figures; v2: references added, minor clarifying additions, matches published versio

Botanical research in the Galapagos islands : the last fifty years and the next fifty

We review recommendations made since the founding of the Charles Darwin Foundation in 1959, concerning botanical research for the conservation of Galapagos, and present our suggestions for priorities for the immediate future

Preconditioned Bi-Conjugate Gradient Method for Radiative Transfer in Spherical Media

A robust numerical method called the Preconditioned Bi-Conjugate Gradient (Pre-BiCG)method is proposed for the solution of radiative transfer equation in spherical geometry.A variant of this method called Stabilized Preconditioned Bi-Conjugate Gradient (Pre-BiCG-STAB) is also presented. These are iterative methods based on the construction of a set of bi-orthogonal vectors. The application of Pre-BiCG method in some benchmark tests show that the method is quite versatile, and can handle hard problems that may arise in astrophysical radiative transfer theory.Comment: 19 pages, 12 figure

The rapid evolution of the exciting star of the Stingray Nebula

SAO244567, the exciting star of the Stingray nebula, is rapidly evolving. Previous analyses suggested that it has heated up from an effective temperature of about 21kK in 1971 to over 50kK in the 1990s. Canonical post-asymptotic giant branch evolution suggests a relatively high mass while previous analyses indicate a low-mass star. Fitting line profiles from static and expanding non-LTE model atmospheres to the observed UV and optical spectra, taken during 1988-2013, allowed us to study the temporal change of effective temperature, surface gravity, mass-loss rate, and terminal wind velocity. In addition, we determined the chemical composition of the atmosphere. We find that the central star has steadily increased its effective temperature from 38kK in 1988 to a peak value of 60kK in 2002. During the same time, the star was contracting, as concluded from an increase in surface gravity from log g = 4.8 to 6.0 and a drop in luminosity. Simultaneously, the mass-loss rate declined from log (dM/dt/Msun/yr)=-9.0 to -11.6 and the terminal wind velocity increased from 1800km/s to 2800km/s. Since around 2002, the star stopped heating and has cooled down again to 55kK by 2006. It has a largely solar surface composition with the exception of slightly subsolar carbon, phosphorus, and sulfur. By comparison with stellar-evolution calculations, we confirm that SAO244567 must be a low-mass star (M < 0.55 Msun). However, the slow evolution of the respective stellar evolutionary models is in strong contrast to the observed fast evolution and the young planetary nebula with a kinematical age of only about 1000 years. We speculate that the star could be a late He-shell flash object. Alternatively, it could be the outcome of close-binary evolution. Then SAO244567 would be a low-mass (0.354 Msun) helium prewhite dwarf after the common-envelope phase, during which the planetary nebula was ejected.Comment: 16 pages, 13 figures, accepted for publication in A&

Nucleic acid delivery to mesenchymal stem cells: a review of nonviral methods and applications

Background: Mesenchymal stem cells (MSCs) are multipotent stem cells that can be isolated and expanded from many tissues, and are being investigated for use in cell therapies. Though MSC therapies have demonstrated some success, none have been FDA approved for clinical use. MSCs lose stemness ex vivo, decreasing therapeutic potential, and face additional barriers in vivo, decreasing therapeutic efficacy. Culture optimization and genetic modification of MSCs can overcome these barriers. Viral transduction is efficient, but limited by safety concerns related to mutagenicity of integrating viral vectors and potential immunogenicity of viral antigens. Nonviral delivery methods are safer, though limited by inefficiency and toxicity, and are flexible and scalable, making them attractive for engineering MSC therapies. Main text: Transfection method and nucleic acid determine efficiency and expression profile in transfection of MSCs. Transfection methods include microinjection, electroporation, and nanocarrier delivery. Microinjection and electroporation are efficient, but are limited by throughput and toxicity. In contrast, a variety of nanocarriers have been demonstrated to transfer nucleic acids into cells, however nanocarrier delivery to MSCs has traditionally been inefficient. To improve efficiency, plasmid sequences can be optimized by choice of promoter, inclusion of DNA targeting sequences, and removal of bacterial elements. Instead of DNA, RNA can be delivered for rapid protein expression or regulation of endogenous gene expression. Beyond choice of nanocarrier and nucleic acid, transfection can be optimized by priming cells with media additives and cell culture surface modifications to modulate barriers of transfection. Media additives known to enhance MSC transfection include glucocorticoids and histone deacetylase inhibitors. Culture surface properties known to modulate MSC transfection include substrate stiffness and specific protein coating. If nonviral gene delivery to MSCs can be sufficiently improved, MSC therapies could be enhanced by transfection for guided differentiation and reprogramming, transplantation survival and directed homing, and secretion of therapeutics. We discuss utilized delivery methods and nucleic acids, and resulting efficiency and outcomes, in transfection of MSCs reported for such applications. Conclusion: Recent developments in transfection methods, including nanocarrier and nucleic acid technologies, combined with chemical and physical priming of MSCs, may sufficiently improve transfection efficiency, enabling scalable genetic engineering of MSCs, potentially bringing effective MSC therapies to patients